Contact

Unraveling Innovations in Drug Delivery: DTU Summer School

Uncategorized / By

Sandeep Karki, a PhD student at the University College Dublin (UCD), and Dr. Sahil Malhotra, a DevelopMed Postdoctoral Researcher at UCD embarked on a two-week academic expedition at the Technical University of Denmark (DTU), spanning from August 21st to September 1st. Here they visited Dr. Nazanin Zanhanizadeh Ezazi, a fellow Postdoctoral Researcher at DTU, and Eleftheria Pantazoglou, a PhD student at DTU. While there they completed a comprehensive summer program and delved extensively into the intricate facets of drug delivery and micro/nano sensor technologies. Their participation was not merely educational but yielded substantial contributions to the realm of pharmaceutical research.

Exploring the Objectives:

DTU’s summer school offered a multifaceted approach to comprehending the nuances of drug delivery:

  1. Scientific Lectures and Presentations: Sandeep, along with his fellow participants, engaged in a diverse spectrum of scientific presentations. These encompassed topics such as oral peptide delivery, innovative transdermal drug delivery methodologies, and the transformative influence of 3D printing within the pharmaceutical sphere.

  2. Poster Presentations: Guided by Nazanin and Eleftheria, Sandeep and Sahil’s research findings and laboratory experiments found their platform through engaging poster presentations, which unveiled potential advancements in drug delivery to a broader academic audience.

  3. Hands-on Experimental Endeavors: The summer program facilitated immersion in practical experiments involving the preparation of drug-loaded patches. Advanced techniques like slot-die coating, 3D printing, and solvent casting were employed, thereby enhancing their grasp of modern drug delivery technologies.

  4. Interactions with Eminent Academics: Notably, Sandeep and Sahil also had the privilege of one-on-one sessions with distinguished Professors Christian Janfelt and Jette Jacobson from the University of Copenhagen. These interactions delved into cutting-edge techniques, including MALDI for peptide analysis and innovative in vivo and ex vivo studies concerning buccal drug delivery.

Achievements and Outcomes:

The team accomplished notable milestones during their tenure at DTU:

  1. Pioneering Bilayered Patches: They successfully crafted bilayered patches, uniquely tailored for efficient drug delivery. These patches underwent comprehensive in vitro release and mucoadhesive studies, underscoring their potential for enhanced drug delivery.

  2. Poster Presentations: They also showcased ongoing projects and the laboratory works completed at DTU. These presentations bore testament to unwavering dedication and the innovation propelling drug delivery research.

  3. Invaluable Knowledge Exchange: Interactions with Professors Janfelt and Jacobson enriched the team’s understanding of novel techniques and exploratory avenues within the domain of pharmaceutical research.

  4. Comprehensive Learning: The exposure to scientific lectures by industry experts broadened insights into the ever-evolving landscape of drug delivery technologies.

The journey at DTU’s summer school was a voyage of scholarly exploration, revealing novel prospects in the realm of drug delivery. The experience holds the promise of not only advancing pharmaceutical research but also potentially enhancing healthcare and patient outcomes.

   In-cheek delivery of peptide-analogue therapies

Linkedin

Powered by Catalyze

Funding statement

This project has received funding from the European Union’s Horizon Europe research and innovation programme under grant number 101071054. Views and opinions expressed are those of the author(s) only and do not necessarily reflect those of the European Union or European Innovation Council. Neither the European Union nor the granting authority can be held responsible for them.

Susie Birney

Patient Advocate

Susie lives in Dublin and volunteers her time to help advocate for others who live with obesity and Type 2 Diabetes. Most recently Susie was involved with Diabetes Ireland in the drafting of the “Talking about Diabetes : Language Matters” Guide. Addressing stigma for either Diabetes or Obesity which Susie has lived experience of,  is high on the list of her priorities and being involved in advisory boards is one example of how to do this by being involved throughout the research process from beginning to end.

Maura Murphy

Retired Civil Servant but currently Voluntary Secretary at ICPO the Irish Coalition for People Living with Obesity

Maura thinks it is important to treat the patient holistically. Over the years, she has been visiting several hospitals for different conditions, and these silos can be exhausting. She is passionate about learning about obesity since she discovered that it is a disease in 2019. Prior to that, her self-blame and stigma held her back. She has learned that obesity is a gateway to other diseases, and she knows this firsthand because she lives with Type 2 Diabetes, Hypertension, Gout, Fluid Retention, and Osteoarthritis. She attends a Chronic Disease Clinic in Ballina every six months, which has thankfully eliminated the silo appointments to three different hospitals and their various departments.

Mary Frances White

Social Care Worker within the community care system/ committee & patient representative for ICPO

Mary Frances is married with one adult child. She has worked for many years as a Social Care worker within Adult services for those with intellectual disabilities. She is SAM’s trained as she dispenses medication on a daily basis (SAM’s = Safe Administering of Medication).

She is also one of the first committee members and a patient representative for an ICPO. They give talks to medical students of many disciplines regarding respect and dignity for people living with obesity. They also hold weekly support meetings and face-to-face meetings when possible. The subject of medications that are becoming available for those who are living with obesity is very topical at present.

Ken Tait

Psychotherapist & International Diabetes Advocate

As a psychotherapist, Ken helps people navigate emotional problems. As a Diabetes Advocate, he supports individuals living with diabetes and advocates for the help and support they need. He serves on many local diabetes boards and gives talks both nationally and internationally to help people and healthcare professionals understand what living with type 2 diabetes is like.

The reason that he joined BUCCAL-PEP was that he likes to keep abreast of what is happening for people with diabetes and how they can manage their diabetes Additionally, he recognizes that some people dislike needles, and this BUCCAL-PEP approach could provide an alternative to help them.

Ken Tait

Psychotherapist & International Diabetes Advocate

As a psychotherapist, Ken helps people navigate emotional problems. As a Diabetes Advocate, he supports individuals living with diabetes and advocates for the help and support they need. He serves on many local diabetes boards and gives talks both nationally and internationally to help people and healthcare professionals understand what living with type 2 diabetes is like.

The reason that he joined BUCCAL-PEP was that he likes to keep abreast of what is happening for people with diabetes and how they can manage their diabetes Additionally, he recognizes that some people dislike needles, and this BUCCAL-PEP approach could provide an alternative to help them.

Javier O. Morales, Ph.D.

Biosketch

Dr. Javier O. Morales is an Associate Professor at the University of Chile, specializing in pharmaceutical science and technology. He heads the Center of New Drugs for Hypertension (CENDHY) and is an Associate Researcher in the Advanced Center for Chronic Diseases (ACCDiS). With a Ph.D. from The University of Texas at Austin, he focuses on innovative drug delivery systems, particularly for peptides, proteins, and poorly water-soluble drugs. His research explores nanoencapsulation and alternative routes of administration. Dr. Morales has a keen interest in buccal absorption and 2D/3D printing for drug delivery. He joined BUCCAL-PEP’s SAB to advance less invasive diabetes treatments and explore synergies with his own research.

Giovanni Traverso, MB, BChir, PhD

MIT and Harvard

Prof. Giovanni Traverso is the Director of the Laboratory for Translational Engineering at MIT and Harvard, an Associate Professor of Mechanical Engineering at MIT, an Associate Physician in Gastroenterology at Brigham and Women’s Hospital, Harvard Medical School, and an Associate Member of the Broad Institute. He received his undergraduate and medical degrees from Cambridge and a PhD from Johns Hopkins, where he pioneered non-invasive cancer detection. His postdoctoral research at MIT focused on advanced drug delivery and gastrointestinal sensing. His current work drives next-generation drug delivery systems and ingestible devices for physiological monitoring.

Prof. Ljiljana Fruk

University of Cambridge

Prof. Ljiljana Fruk is a Professor of Bionano Engineering at the Department of Chemical Engineering and Biotechnology at University of Cambridge.  Her research encompasses the design and development of nanoscale materials for biomedical applications, including design of drug nanocarriers for solid tumours and biosensors for early detection of cancer. She is particularly interested in development of nature-inspired structures, and has also made significant contributions to development of hybrid bio-nano materials and their application in photocatalysis and sustainable manufacturing. She is one of the co-founders of Senesys Bio, Cambridge spinout developing therapeutic formulations for senescent cell removal. Prof Fruk is an active science popularizer, art-science curator, and the co-author of the field-establishing Molecular Aesthetics book (MIT Press 2013), and the first textbook on Bionanotechnology (Cambridge University Press 2021).

Dr. Eva Roblegg

University of Graz

Dr. Eva Roblegg is a full professor at the University of Graz, specializing in pharmaceutical technology and biopharmacy. She leads the Drug Delivery and Advanced Manufacturing group and focuses on the development of nano drug delivery systems (nanoDDS) for the treatment of oral diseases, such as oral mucositis. To better understand the relationship between nanoDDS and buccal/sublingual tissues, her group has developed in vitro cell and tissue models that mimic healthy and inflamed human oral mucosa. Eva Roblegg works closely with the Research Center Pharmaceutical Engineering, a center of excellence in Graz, Austria, where she is involved in advanced technologies for the continuous manufacturing and conversion of (nano-)drug delivery systems into final dosage forms. Given her research interest in this area and the opportunity to create further synergies with her own research, she has joined BUCCAL-PEP’s SAB.

Dr. Andrew Muddle

MedPharm

Dr. Andrew Muddle, founder and former CEO of MedPharm, brings over 30 years of pharmaceutical industry experience in drug delivery. He played a pivotal role in PowderJect Pharmaceuticals plc’s early development and IPO, and his career includes positions at Elan Corporation, Ethical Pharmaceuticals Ltd (U.K.), Controlled Therapeutics (Scotland), and Ciba-Geigy (now Novartis). Dr. Muddle excels in managing projects to commercialization, specializing in transdermal and topical products. He joined BUCCAL-PEP due to the challenge of oral peptide delivery.